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  1. During initial stages of tumor development, macrophages can either directly promote antitumor responses by killing tumor cells or indirectly recruit and activate other immune cells. However, the mechanism of anti-CD47 monoclonal antibody (mAb) treatment remains controversial. Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent immunosuppressive Breast cancer is a major threat of women’s health worldwide. In this study, we found that circATP8A1, a previously unreported circular Mar 5, 2023 · CD206‐expressing TAMs have immune‐stimulatory functions in the early stages of lung cancer. Adipose tissue expansion in obesity alters the balance between pro- and anti-inflammatory macrophages, which is a primary cause of inflammation. We used zwitterionic buffers to adjust the pH in series of in vitro experiments. Notably, macrophages are highly plastic cells and, depending on the microenvironmental cues in the Tumor Microenvironment (TME), can undergo marked changes in Feb 2, 2022 · Breast cancer is a major threat of women’s health worldwide. 1a). . The IHC data showed that in the stroma area, SENP3 staining intensity was negatively correlated with the levels of CD68, a macrophage marker, with statistical significance ( n Apr 18, 2021 · In established cancers, high macrophage infiltration often strongly associates with poor prognosis or tumor progression in many types of solid tumors, including breast , bladder , head and neck , glioma , melanoma , and prostate cancer . Obesity is associated with an increased incidence of cancers, and multiple mechanisms link obesity with cancer initiation and progression. Apr 10, 2024 · It has been reported that SPP1 blockade with an RNA aptamer could inhibit cancer progression and prolong The role of tumor-associated macrophages in the progression and chemoresistance of Jun 16, 2021 · Single-cell RNA sequencing and imaging of macrophages in human non-small cell lung cancer and in a mouse model of lung adenocarcinoma show that tissue-resident macrophages have a key role in early We identified a gene-MSR1-characterized by chromatin accessibility, associated with poor prognosis in gastric cancer. Nov 11, 2017 · The two faces of macrophages. In this study, we reported that PGAM1 suppr … Jul 10, 2023 · In this review, we outline the various known TAM populations found thus far and delineate their specialized roles associated with the main stages of cancer progression. In this review, we discuss the roles tumour-associated macrophages (TAMs) play in regulating different steps of tumour progression and metastasis, and the opportunities to target them in the quest for cancer Apr 22, 2024 · Background: Cancer cells are capable of evading clearance by macrophages through overexpression of anti-phagocytic surface proteins known as "don't eat me" signals. The vital component of the TME is tumor-associated macrophages (TAMs), which are Dec 2, 2022 · Macrophages participate in the homeostasis of adipose tissue and play an important role in cancer. Jun 1, 2024 · Macrophages in colorectal cancer: orchestrating growth, invasion, and immune modulation. ERK, EMT, and Wnt signaling pathways were activated in cancer cells due to HMGB1 upregulation. Aug 29, 2018 · Background: Accumulating evidence suggests that M2-polarized tumor-associated macrophages (TAMs) play an important role in cancer progression and metastasis, making M2 polarization of TAMs an ever more appealing target for therapeutic intervention. 7 Targeted Inhibition of MALAT1 Suppresses the Promotion of Gastric Cancer Progression by M2-Polarized Macrophages and Improves Chemotherapy Efficacy We performed in vivo animal studies to explore the effect of M2-EX on gastric cancer progression. Oct 28, 2023 · Therefore, macrophage-related inflammation functions as a crucial mediator linking obesity and cancer progression [6,24,25]; however, the underlying molecular mechanism remains unclear. Prostate cancer (PCa) is the second most frequently diagnosed cancer among men worldwide. Moreover, the number of CD163<sup>+</sup>CD2 … Nov 20, 2021 · Strategies for cancer treatment have traditionally focused on suppressing cancer cell behavior, but many recent studies have demonstrated that regulating the tumor microenvironment (TME) can also inhibit disease progression. Exosomes serve as cargo for circRNAs and play a crucial role as mediators in facilitating communication between cancer cells and the tum … Apr 11, 2020 · Macrophages play an important role in the immune system as a key host defense against pathogens. demonstrated that MK2 signaling/angiogenesis is inherent in macrophages; MK2 regulates CXCL12 expression in TAMs, promoting angiogenesis and progression of cancer cells . HMGB1 was secreted into the extracellular space of lactate-induced macrophages, further enhancing the malignant behaviors of cancer cells. Jun 29, 2021 · The M1/M2 macrophage paradigm plays a key role in tumor progression. Recent Findings EMT is a crucial process in tumor progression. In fact, TAMs represent the dominant immune cell population of BC tumor microenvironment (TME) and they have been correlated with poor prognosis and increased metastatic potential. Macrophages play a crucial role in the development and progression of colorectal cancer (Liu et al. A large body of evidence demonstrates that various mechanisms of crosstalk exist between macrophages and tumor cells that have undergone EMT resulting in a vicious cyc … Mar 26, 2021 · To facilitate the use of macrophages in cancer immunotherapy, we summarize their related characterization and research progress in this review. Jul 3, 2018 · We also uncovered the direct interaction between CB2 and TLR4 and deciphered its role in macrophage activation. It is driven not only by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between cancer cells and their altered microenvironment components. Different directions of TAM polarization result in opposite functions in cancer progression. The TME is characterized by the infiltration of a series of immune cells. 1a). In human primary endometrial cancers, loss of LKB1 protein was strongly associated with increased CCL2 expression by tumor cells as well as increased macrophage density in the tumor microenvironment. 8 million deaths (18% of the total cancer deaths) worldwide (1,2). In cancer progression, angiogenesis, which can be promoted by TAMs, is an indicator of tumor IL-4/STAT6 pathway regulated YY1, and YY1 increased the macrophage-induced PCa progression by upregulating IL-6. The mutual interactions with tumor cells and stromal microenvironment contribute to phenotypically polarization of tumor associated macrophages. Methods: Exosomes were extracted from bladder cancer cells MB49 conditioned medium by ultracentrifugation. Jun 18, 2021 · 1. Tumor-associated macrophages (TAMs) are the key cells that create an immunosuppressive tumor microenvironment (TME) by producing cytokines, chemokines Alterations in the tumor microenvironment are closely associated with the metabolic phenotype of tumor cells. Genetic or pharmacologic inhibition of PI3Kγ restores antitumor immune responses and improves responsiveness to standard-of-care chemothe … Feb 27, 2023 · Purpose of Review The purpose of this review is to summarize the recently published findings regarding the role of epithelial to mesenchymal transition (EMT) in tumor progression, macrophages in the tumor microenvironment, and crosstalk that exists between tumor cells and macrophages. Macrophages are major TME components, and the direction of phenotype polari … We report here that PI3Kγ regulates macrophage transcriptional programming, leading to T-cell suppression, desmoplasia, and metastasis in pancreas adenocarcinoma. Macrophages and fibrillary collagen in ECM Fibrillary collagen is an important substrate of the extracellular matrix. Using the N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) model of bladder cancer, we previously showed that MIF knockout mice display decreased angiogenesis and invasion compared with wild-type. Macrophages consist of at least two subgroups, M1 and M2. Distinct Tumor-associated macrophages (TAM) play a crucial role in promoting cancer progression. In this study, the effect and mechanism of MANF on cervical cancer were This study aimed to delineate the molecular mechanisms of PCa progression under HFD milieus and define the stromal microenvironment focusing on macrophage inhibitory cytokine-1 (MIC-1) activation. M2-polarized tumor-associated macrophages (M2 TAMs) promote cancer progression. Clinical correlative data Sep 7, 2023 · In summary, exosomal NOX1 promotes tumor-associated macrophage M2 polarization-mediated cancer progression through stimulating ROS production in cervical cancer. Numerous studies using human breast cancer samples, cell lines, and murine … Apr 28, 2024 · M1 macrophages could produce inflammatory cytokines such as interleukin (IL)‐6 and IL‐1β, killing tumour cells and pathogenic microorganisms whereas M2 macrophages secret growth factors such as epidermal growth factor (EGF) participating in the tissue remodelling or tumour progression. Macrophages participate in the homeostasis of adipose tissue and play an important role in Nov 6, 2021 · Macrophage-mediated RON signaling supports breast cancer growth and progression through modulation of IL-35 Jul 8, 2024 · A substantial amount of evidence has supported the involvement of tumor associated macrophages (TAMs) in cancer progression and metastasis in various types of cancer, including BC (8–10). Feb 1, 2022 · Breast cancer is a major threat of women’s health worldwide. TAMs promote tumor progression by secreting Jul 9, 2024 · It highlights the constant interplay between TAMs and breast cancer cells and its major contribution to the progression of the disease, including such aspects as, polarization of macrophages toward a tumor promoting phenotype, induction of epithelial to mesenchymal transition (EMT) in cancer cells and enhancement of cancer stem cell properties. Jul 12, 2019 · Tumor metastasis is a major contributor to the death of cancer patients. at/) [17], the enrichment of macrophage subsets in 14 solid tumors was assessed by gene set enrichment analysis (GSEA), immune cell types and proportions in STAD were identified by the CIBERSORT algorithm, and M1/M2 macrophage distribution in different stages of STAD were further estimated Apr 19, 2024 · 2. Phosphoglycerate mutase 1 (PGAM1) is a key enzyme involved in cancer Goossens, Rodriguez-Vita et al. Exosomes mediate cellular communication in the tumor microenvironment (TME). The global cancer incidence and prevalence statistics of 2020 indicated that breast cancer has surpassed lung cancer to become the most common form of cancer prevalent in women today. BST2 was predicted to be associated with the infiltration of TAMs. Aug 16, 2022 · By contrast, in most established tumours, macrophages contribute to cancer progression and metastasis by various mechanisms, including promotion of cancer cell survival and proliferation, Aug 11, 2023 · JMJD6 is upregulated in TAMs and indicates poor prognosis of cancer. May 15, 2024 · Immunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a key enzyme involved in cancer metabolism while its role in remodeling TME remains unclear. … Jan 1, 2022 · Introduction. In this study, we explored the immunosuppressive effect of B7-H3 (CD276) via the CCL2-CCR2-M2 macrophage axis and its potential as … Jan 1, 2023 · They identified IL6 and IL10 as potential candidates released from the M2 macrophages that trigger cyclin D and STAT3 activation in SKOV3 cancer cells leading to cancer cell cycle progression (Takaishi et al. In regular conditions, intestinal macrophages serve to Sep 28, 2023 · Models for TAM polarization. Methods: We investigated the effects of HFD on PCa stromal microenvironment and MIC-1 signaling activation using PC-3M-luc-C6 PCa model mice fed with Feb 19, 2022 · Cancer immunotherapy has emerged as a novel cancer treatment, although recent immunotherapy trials have produced suboptimal outcomes, with durable responses seen only in a small number of patients. As vital components of the immune system, they possess diverse functionalities and mechanisms that can combat tumor growth. Introduction. Metastasis is a process in which malignant cells spread beyond the primary tumor to a distal region to cause the development of new secondary tumors or throughout the whole body in advanced cancers. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. The aim of the present study was to investigate the role of M2 Arg-1+ MФ in tuberculous pleurisy-assisted Apr 3, 2024 · Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. Article CAS PubMed Google New approaches beyond PD-1/PD-L1 inhibition are required to target the immunologically diverse tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC). Mar 8, 2024 · Circular RNAs (circRNAs) play important roles in gastric cancer progression but the regulatory role of circRNAs in controlling macrophage function remains elusive. Results Infiltration of M0 macrophages was significantly higher in HCC tissues than in normal liver tissues (P = 2. In an oversimplified manner, macrophages in the TME were previously distinguished into the pro-inflammatory M1 type-linked to antitumor functions and the anti-inflammatory M2 type-endowed with tumor promoting capabilities (). Oct 24, 2017 · In a mouse model of breast cancer, Lin et al showed that a homozygous null mutation of a gene encoding the macrophage growth factor, colony stimulating factor-1 (CSF-1), not only reduced Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor-associated macrophages (TAM) is poorly understood. Cancer cells’ bidirectional metabolic interactions with TAMs are hypothesised to contribute to carcinogenesis via altered metabolism metabolites. M2a macrophages produce fibronectin The “NETotic complex” contains a few stages, including vacuolization Aug 8, 2023 · Introduction. Thus, the role of TRMs in cancer growth seems to be organ-specific. May 22, 2023 · MDSCs play a crucial role in inhibiting innate and T-cell responses in cancer. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic outcomes in cancer through angiogenic and lymphangiogenic regulation, immune suppression May 1, 2018 · Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. Apr 3, 2020 · Peritoneal macrophages promote ovarian cancer progression Ovarian cancer is the most lethal gynaecological disease in women, with ~300,000 new diagnoses worldwide in 2018 and an overall survival Feb 15, 2023 · Tumour progression is modulated by the local microenvironment. The role of tumor-associated macrophages in the Jul 21, 2021 · In this review, mechanisms underlying the distinct functional characterization of M1 and M2 macrophages are demonstrated to make sense of M1 and M2 as key regulators during cancer progression. As the tumor grows, macrophages in the May 31, 2016 · As with breast cancer, MARCO expression correlated with macrophage and M2 TAM-related genes as well as markers of EMT (Figures S6 B and S6C). In association with EMT changes, macrophage Jul 3, 2018 · Functionally, macrophage MGLL inhibits CB2 cannabinoid receptor-dependent tumor progression in inoculated and genetic cancer models. The role of macrophages in tumourigenesis has been controversial. Jul 9, 2024 · tumor associated macrophages (TAMs) in cancer progression and metastasis in various types of cancer, including BC (8–10). Although current treatments for lung cancer include surgery, radiotherapy, chemotherapy, and targeted therapy, the overall prognosis is relatively poor due to tumor progression and metastasis (3,4). H. Cancer-associated fibroblasts (CAFs) play a pivotal role in tumor growth and metastasis. 1 PCa accounts for a quarter of diagnosed cancer cases, with the second highest mortality rate in the USA. They can adopt two distinct phenotypes, primarily determined by environmental cues. Targeting cholesterol efflux in macrophages counters this reprogramming and reduces tumor progression in a model of ovarian cancer. Astragaloside IV (AS-IV), a saponin component isolated from Astragali radix, has been reported to EMT is a crucial process in tumor progression. Until now, the association between EVs and miR-130b-3p has seldom discussed, and this topic needs further verification. Here, we report that macrophage-s … Jan 18, 2021 · Colorectal cancer (CRC) is the third most common cancer worldwide. Unfortunately, this approach has not provided clinical breakthroughs that have changed Jul 25, 2022 · In a lung cancer model, macrophages of both origins contributed to tumor growth and progression 43. Jan 31, 2017 · Breast cancer initiation, progression and metastasis rely on a complex interplay between tumor cells and their surrounding microenvironment. Macrophages, the cells of the innate immune system that normally exert antitumor activities, can be educated by tumors to an alternatively activated phenotype that is known to promote tumor progression. This gene dictates the progression of gastric cancer by facilitating M2 macrophage polarization. This environment is populated by many immune cells, of which macrophages are among the most abundant. In this study, we preliminarily investigated the upstream pathway of M2 macrophage polarization affecting lung cancer progression. 1 2 Due to a lack of obvious symptoms at the initial stages, approximately 20% of the patients with PCa are diagnosed with advanced disease, resulting in distant metastasis and death. (Fig. Sep 8, 2017 · Therefore, in addition to other described activities of macrophages to promote tumour growth and progression when interacting with cancer cells, in this experimental setting, one important Macrophage migratory inhibitory factor (MIF) is a proinflammatory cytokine shown to promote tumorigenesis. 7). Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor Dec 1, 2022 · These macrophages are predominantly found infiltrated and differentiated within the TME and are known as “tumour-associated macrophages” or TAMs at all stages of tumour growth . The tumor microenvironment (TME) has been shown to be responsible for tumor immune escape and therapy failure. Moreover, both M1- and M2-like macrophage polarization-associated proteins were induced in macrophages cocultured with RACK1-silenced cell supernatant. However, incorporating macrophages into these spheroid cultures poses specific Feb 10, 2024 · In vitro experiments demonstrated that dasatinib, a Src inhibitor, promoted M2-like macrophages to polarize toward M1-like macrophages in cisplatin-resistant lung cancer cell lines A549R and H460R Feb 1, 2024 · Jang, J. Mesencephalic astrocyte-derived neurotrophic factor (MANF) has been widely recognized as an anti-inflammatory factor to regulate macrophage polarization. HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage Jul 21, 2021 · In this review, mechanisms underlying the distinct functional characterization of M1 and M2 macrophages are demonstrated to make sense of M1 and M2 as key regulators during cancer progression. Keywords: Cancer; Metastasis; Polarization; Tumor-associated macrophages. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity and immunosuppressive tumor promotion. Nov 23, 2023 · Here the authors report that ID1-expressing tumor associated macrophages favor colorectal cancer progression by promoting cancer cell stemness and CD8+ T cell exclusion. Despite advances in cancer treatment, cancer metastasis remains the principal cause of cancer-related deaths. Methods Multidimensional bioinformatic methods were used to construct a risk score model using M0 macrophage-related genes (M0RGs). Dec 29, 2021 · Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. In our study, the expression of IL-6 in tumor tissues from 36 gastric cancer (GC) patients was significantly higher than in non-tumor tissues. To understand the role of JMJD6 in cancer, the expression levels of JMJD6 in different tumor-infiltrating cell subgroups were evaluated with flow cytometry assays in Lewis lung carcinoma (LLC) tissues (Fig. Sep 14, 2021 · However, the mechanism of tumor derived exosomes promotes bladder cancer progression have not been defined. In association with EMT changes, macrophage infiltration of tumors occurs frequently. Although many studies have explored the mechanisms underlying TAM polarization and its immunosuppressive functions, understanding of its progression remains limited. Jul 21, 2021 · Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression. A mechanistic study revealed that the expression and secretion of C-C motif chemokine 2 (CCL2), C-C motif chemokine 5 (CCL5), interleukin-6 (IL-6), and interleukin-1 (IL-1) are closely related Tumor-associated macrophages (TAMs) are the most prominent immune cells in the breast cancer microenvironment, and the protumor functions of TAMs are thought to affect cancer progression and resistance to anticancer therapy. Interleukin 6 (IL-6) was abundant in the tumor microenvironment and played potential roles in tumor progression. Tumor cell-derived spondin 2 (SPON2) is an extracellular matrix glycoprotein that has complicated roles in recruitment of macrophages and neutrophils during inflammation. We also verified MARCO expression by immunofluorescence by triple staining with CD68 and the M2 marker CD163 ( Figure S6 D). M1 phenotype macrophages are tumor-resistant due to intrinsic Aug 11, 2023 · The tumor-associated macrophage (TAM) is the most abundant group of immune cells in the tumor microenvironment (TME), which plays a critical role in the regulation of tumor progression and Dec 15, 2021 · INTRODUCTION. This finding suggests that the combination of anti-macrophage therapy may improve the efficacy of VDR activation therapy in PAAD. The dichotomy of the conventionally defined ‘M1’ and ‘M2’ macrophage polarization program, as pro- (M1) and anti- (M2) inflammatory stages of their phenotypic program, has served as a valuable framework for understanding and classifying the extremes of TAM phenotypes (left). Lung cancer is a leading cause of cancer deaths. Feb 19, 2022 · Recent research has shown that cisplatin-induced macrophages promote tumor progression and metastasis in ovarian cancer via the CCL20-CCR6 axis, which can be targeted therapeutically to reduce drug-induced metastasis in advanced-stage ovarian cancer . doi: 10. miRNA let-7b-5p overexpression domesticates macrophages towards M2-subtypes through regulating the SOCS1/STAT pathway, followed by prostate cancer progression . Monoclonal antibodies that antagonize the "don't-eat-me" signaling in macrophages and tumor cells by targeting phagocytic checkpoints have shown therapeutic promises in several canc Background: Macrophage colony-stimulating factor (CSF1), also known as colony-stimulating factor-1 (CSF1), and its receptor CSF1R have been correlated with poor prognosis in many cancer types including breast cancer. The effect of LAMP2a-knockdown on tumor progression and TME maintaining was determined by using mouse tumor models. Over-expression of both … Macrophages: modulators of breast cancer progression Mar 11, 2022 · The omics era made possible the quest for efficient markers for cancer progression and revealed that macrophage populations are much more complex than just the M1/M2 dichotomy. Chronic low-grade inflammation driven by macrophages is also an important characteristic of cancer. Oct 9, 2023 · Prostate cancer (PCa) is a prevalent malignant neoplasm affecting the male reproductive system globally. Herein, we investigated the prognostic impact of CSF1 and CSF1R expression in tumor epithelial and stromal compartments in Feb 10, 2005 · The interaction of lung cancer cells and macrophages can promote the invasiveness and matrix-degrading activity of cancer cells. Thus, the role of TRMs in Dec 2, 2022 · Abstract. Apr 20, 2024 · Tumor-associated macrophages (TAMs) are abundant in tumors and interact with tumor cells, leading to the formation of an immunosuppressive microenvironment and tumor progression. Furthermore, by conducting H3K27ac-ChIP-seq in M2 macrophages and THP-1, we found that thousands of enhancers were gained during M2 macrophage polarization, and these M2-specific enhancers were enriched in YY1 ChIP-seq signals. Poor expression of miRNA-203 (miR-203) within PCa tissues and cells implies its potential utilit … Feb 23, 2021 · HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway Siqi Zhou; Zhangding Wang; Xiaoping Zou; World Jan 28, 2023 · Also, macrophages showed no promoting effect on cancer cell growth and migration in the presence of 3-OBA. Apr 12, 2024 · UA treatment inhibits breast cancer in tumor macrophage co-culture and organoid models. Based on different polarization status, TAMs may also induce antitumor immune responses o … May 12, 2024 · Background Cervical cancer is a common gynecologic malignant tumor, but the critical factors affecting cervical cancer progression are still not well demonstrated. However, the diagnostic and therapeutic approaches fall short of meeting the demands posed by PCa. et al. Apart from environmental factors, such as smoking, alcohol, and obesity, genetic and epigenetic alterations contribute to the development and progression of CRC, including loss-of-function mutations of p53 and APC and gain-of-function of β-catenin and MAPK 2. Dec 29, 2021 · In summary, TAMs are a double-edged sword since sometimes they promote tumor clearance whereas sometimes they accelerate cancer progression and treatment resistance. 34 In Jul 12, 2021 · Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Breast cancer cell-derived soluble CD44 promotes tumor progression by triggering macrophage IL1 beta production. In 2020, it caused approximately 1. Jul 3, 2018 · The TAM MGLL-CB2 axis regulated the activation of tumor-associated CD8+ T cells and the progression of multiple cancers. Cancer Res. TAMs have been involved in producing immuno-suppressive TME in the tumor by generating inflammatory mediators, growth factors, cytokines, chemokines, etc … Nov 1, 2022 · Using the Cancer Immunome Database (TCIA) (https://tcia. In …. 1 Apr 10, 2024 · High expression of VDR in PAAD promotes M2 macrophage polarization and recruitment through the secretion of CCL20, which activates tumor progression. Mechanistically, MGLL deficiency promotes CB2/TLR4-dependent macrophage activation, which further suppresses the function of tumor-associated CD8+ T cells. Jun 13, 2017 · Targeting CD47 efficiently enhances macrophage phagocytosis in both physiological and pathological conditions. Apr 24, 2023 · Background. In vitro mouse primary macrophages were used to assess LAMP2a-modulated macrophage activation, and to verify LAMP2a's target proteins. Our results also suggest that a great diversity of gene expression occurs in this interaction, which may assist us in understanding the process of cancer metastasis. Jun 18, 2021 · Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths. According to Stephen Paget's "Seed and Soil" hypothesis, metas … Jul 1, 2022 · The omics era made possible the quest for efficient markers for cancer progression and revealed that macrophage populations are much more complex than just the M1/M2 dichotomy. M2 macrophage-derived exosomes promoted Hela cel … Jul 21, 2023 · JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis Article Open access 11 August 2023 Introduction Nov 2, 2015 · Inactivation of Ccl2 in an Lkb1-driven mouse model of endometrial cancer slowed tumor progression and increased survival. May 14, 2013 · Therefore, this draws attention to the importance of the ECM and macrophages in breast cancer progression and even targeted therapy. Here, we identified tumor-associated macrophages (TAMs) as regulators of genes in CRC. Apr 12, 2024 · An increased prevalence of M2 macrophages in breast cancer TME, Zhao J, Wang H, Chen J, Wu J. Feb 9, 2023 · Recent studies have revealed that tumor-associated macrophages are the most abundant stromal cells in the tumor microenvironment and play an important role in tumor initiation and progression. Targeting CB2 in macrophages delayed cancer progression (Supplementary Fig. Upon cytokine stimulation, TAM preferentially polarize to the anti-inflammatory and pro-tumor M2 subtype. Furthermore, the proportion of macrophages in the tumor microenvironment is associated with the prognosis o … The tumor-associated macrophage (TAM) is the most abundant group of immune cells in the tumor microenvironment (TME), which plays a critical role in the regulation of tumor progression and treatment resistance. 80 , 1342–1356 (2020). We aimed to investigate potential roles of LRRC75A-AS1 delivered by M2 macrophage exosomes in inducing cervical cancer progression. Fatty acid-binding protein 4 (FABP4), also known as A-FABP, is an adipose-derived FABP that participates in the dissolution and transport of free saturated Aug 31, 2020 · Collectively, these data indicate that tumor-derived exosomal TRIM59 converts macrophages to tumor-promoting functions of macrophages via regulating ABHD5 proteasomal degradation, to activate NLRP3 inflammasome signaling pathway to promote lung cancer progression by IL-1β secretion. 2024 Apr 8;12(4):e007808. , 2021a). Availability of data and materials The data sets used or analyzed during the current study are available from the corresponding author on reasonable request. Feb 27, 2024 · In lung cancer, macrophages constitute the major leukocyte infiltrate (30–50% of stromal cells) and play a pivotal role in the malignant progression of most lung cancer subtypes, with lung adenocarcinoma (LUAD) harboring the highest infiltrate of macrophages [[16, 133, 134]]. The effects of MB49-derived exosomes on macrophages polarization were analyzed by qPCR, flow cytometry, and Western blot. 4-um pore size. May 29, 2021 · Given that macrophage‐specific SENP3 deletion promoted breast cancer progression in mice, we examined the level of SENP3 in macrophages in human breast cancer tissues. Mar 15, 2023 · Tumor-associated macrophages (TAMs) fuel the evolution of the cancer ecosystem. Cancer stemness refers to the stem cell-like phenotype of cancer cells, which has been thought to play a major role in cancer development. Dec 20, 2023 · Lung metastasis is the major cause of death in patients with triple-negative breast cancer (TNBC). In total, the expressions of 457 genes were dysregulated after TAM coculture; specifically, 344 genes were up-regulated, and 113 genes were down-r … Aug 1, 2021 · Our data suggest that BM-derived cells are recruited to the pancreas during carcinogenesis and that the specific subpopulation of BM-derived macrophages partially converted into CAF-like cells, acted as leading cells, and facilitated pancreatic cancer progression. Tumor-associated macrophages (TAMs) are defined as being of an M2-type and are considered as the Sep 7, 2022 · As an inhibitory regulator of JAK/STAT signaling, suppressor of cytokine signaling (SOCS) negatively regulates the state of macrophages and dendritic cells . 9, 10 Previous research showed that tumour‐recruited Jan 1, 2023 · Background: Tumor-associated macrophages (TAMs) are one of the most prominent tumor-infiltrating immune cells in the tumor microenvironment (TME) of CRC and play a vital role in the progression of CRC. The TAM MGLL-CB2 axis regulated the activation of tumor-associated CD8+ T cells and the progression of multiple cancers. 3 Macrophages regulate tumor progression. Here, we report that expression of adipocyte/macrophage fatty acid-binding protein (A-FABP) in TAM promotes breast cancer progression. Apr 8, 2024 · Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responses Bo Wang , # 1, 2 Bingkun Zhou , # 1, 2 Junyu Chen , # 1, 2 Xi Sun , # 1 Wenjuan Yang , 2, 3 Tenghao Yang , 1, 2 Hao Yu , 1 Peng Chen , 1 Ke Chen , 1 Xiaodong Huang , 1 Xinxiang Fan , 1 Wang He Jul 9, 2024 · 2. , 2010). At the initial stages of tumor formation, macrophages mainly play a proinflammatory role and suppress tumor development, although the related evidence is still limited . The mechanism underlying such preferential polarization remains elusive. In recent years, there have been significant strides in this area, particularly with the emergence of 3D spheroids as a model system for drug screening and therapeutics development for solid tumors. A Schematic showing the cancer cells cocultured with macrophages in a transwell chamber of 0. SIGLEC10 is identified as a novel tumor-associated macrophage-related immune checkpoint in other cancer types. Obesity induces multifactorial effects such as dyslipidemia, insulin resistance, and arterial hypertension that influence the progression of many diseases. B Colony formation assays were performed to detect the proliferative capacity of BT-549 and 4 T1 cells after coculturing with macrophages and UA May 8, 2024 · Background The association between tuberculous fibrosis and lung cancer development has been reported by some epidemiological and experimental studies; however, its underlying mechanisms remain unclear, and the role of macrophage (MФ) polarization in cancer progression is unknown. Distinct TAM subtypes in breast cancer progression and prognosis. Nov 21, 2017 · In addition to their roles in normal physiological conditions, macrophages also play crucial roles in disease conditions such as cancer. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. 299e Aug 20, 2022 · Macrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Infiltrating immune cells, including macrophages, promote mammary tumor progression and metastasis; however, less is known about the role of macrophages in ear … Jun 7, 2022 · For example, IL-10 produced by M2 macrophages promotes progression of non-small cell lung cancer through the JAK1/STAT1/NF-kB/Notch1 pathway . To explore the underlying mechanism of TAM-induced tumor progression, TAMs w … TAMeless traitors: macrophages in cancer progression and metastasis Shweta Aras1 and M Raza Zaidi*,1 1Fels Institute for Cancer Research and Molecular Biology, and Department of Medical Genetics Dec 7, 2023 · Background Recapitulating the tumor microenvironment (TME) in vitro remains a major hurdle in cancer research. 30 The Group 2 cluster was FCN1 high and CD204 low, and it is known that FCN1 was highly expressed in monocytes, but expression was low in macrophages. Metastasis is a multistage event in which cancer cells escape from the primary tumor survive in the circulation and disseminate to distant sites. Anti-CD47 antibodies have been shown to inhibit the progression of several types of cancer. 33 CD206‐expressing macrophages were suggested to be resident cells in the breast. In fact, TAMs represent the dominant immune cell population of BC tumor microenvironment (TME) and they have been correlated with poor prognosis and Apr 8, 2024 · Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responses J Immunother Cancer . 1 Histological classification of breast cancer based on the expression of estrogen receptor (ER), progesterone receptor (PR), and/or human epidermal growth factor receptor‐2 (HER2) has been Jul 13, 2020 · Moreover, transfer of M2 macrophage-derived EVs to colon cancer cells could explain the manner in which immune cells are implicated in tumor progression . Immunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer therapy. Herein, it is reported that M2 TAMs-derived exosomes ind … Apr 1, 2022 · With cancer progression, tumor cells generate relevant signaling molecules to induce macrophages to recruit themselves to the tumor site and to polarize toward the M2 phenotype for tumor growth promotion. Macrophages have conventionally been considered to be anti-tumourigenic in nature, play tumour-suppressive roles, and illustrate a significant link between high density and better prognosis, particularly in the case of colorectal cancer. However, direct evidence linking metabolic syndrome to TS-mediated LC progression Tumor-associated macrophages (TAMs), one of the most common cell components in the tumor microenvironment, have been reported as key contributors to cancer-related inflammation and enhanced metastatic progression of tumors. Non-polarized macrophages can differentiate into pro-inflammatory classical pathway-activated macrophages or anti-inflammatory alternative pathway-activated macrophages, both of which play central roles in breast cancer growth and progression in a process called polarization of macrophages Jul 19, 2022 · Background The role of M0 macrophages and their related genes in the prognosis of hepatocellular carcinoma (HCC) remains poorly characterized. Macrophages are recruited through the local expression of chemoattractants such as colony stimulating factor 1 (CSF-1) and macrophage chemoattractant protein 1. This review discusses recent advances in our knowledge of macrophages in the tumor microenvironment, broadly covering TAM functions, factors that shape macrophage heterogeneity, macrophage and tumor co-evolution, and therapeutic opportunities. Methods: We analysed publicly available data of human prostate cancer for linear correlation between macrophage markers and glycolysis genes. We demonstrated LRRC75A-AS1 was highly expressed in exosomes from M2 macrophages which could be absorbed by Hela cells. Sep 24, 2015 · Scientific Reports - Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression. Colorectal cancer (CRC) is a major public health issue due to its high incidence and death rates globally 1. Existing studies have suggested that lactate produced by tumor cells can activate CAFs, yet the preci … Jun 8, 2024 · Tobacco smoking (TS) is implicated in lung cancer (LC) progression through the development of metabolic syndrome. 1136/jitc-2023-007808. Nontumor cell components play crucial roles in cancer. However, the roles of exosomes from M2 TAMs in gastric cancer progression are unclear. In another study by Yang and co-workers, it revealed that TAMs boost CDK2 and CDK4 expression levels in SKOV3 cells while CDK2 Mar 8, 2024 · Circular RNAs (circRNAs) play important roles in gastric cancer progression but the regulatory role of circRNAs in controlling macrophage function remains elusive. However, its potential f … Tumor associated macrophages (TAMs), located in the tumor microenvironment (TME), play a significant role in cancer cell survival and progression. Therefore, the elucidation of their functions in tumorigenesis requires further exploration. However, its immunosuppressive role and clinical significance in GC … SIGLEC10 + macrophages drive gastric cancer progression by suppressing CD8 + T cell function Aug 6, 2021 · By adoptive transfer of WT macrophages into MK2 KO mice, Suarez-Lopez, L. Exosomes serve as cargo for circRNAs and play a crucial role as mediators in facilitating communication between cancer cells and the tumor microenvironment. Apr 18, 2021 · Macrophages also play diverse roles in cancer development, ranging from antitumor activity in early progression stages to, most commonly, tumor-promoting roles in established cancer . show that cancer cells scavenge membrane cholesterol from tumor-associated macrophages, resulting in their reprogramming toward an immune-suppressive and tumor-promoting phenotype. As genetic changes occur within the tumor or T helper 2 (T H 2) cells begin to dominate the TME, TAMs begin to exhibit an immunosuppressive protumor phenotype that Analysis of invasion, morphometric measurements, and flow cytometry results underscores the substantial contribution of macrophages to tumor progression, while the presence of T cells is associated with a deceleration in the migratory behavior of both cancer cells and macrophages. Methods: Bioinformatics analysis was used to evaluate genes closely associated with lung adenocarcinoma and their relationship with immune cells. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. THP-1 monocytes were induced into M2 macrophages. Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor-associated macrophages (TAM) is poorly understood Sep 28, 2021 · Background: Tumor-associated macrophages (TAMs) are key regulators of the complex interplay between cancer and the immune microenvironment. zkaky hgsw hghqlr ftmacz uvou bxt addssoi lakqa uvevts yqilap